In the process of droplet formation, large molecules or cells suspended in the liquid being nebulized are forcefully distributed from the liquid into the forming secondary droplet. This creates a transient laminar flow in the microcapillary "nebulization" channel formed between the surface of the liquid and the forming secondary droplet. The laminar flow in the capillary channel exerts sufficient shearing forces to break cells. The shearing force created depends on the gas pressure applied, the type of gas, and the viscosity of the liquid. This makes it possible to precisely regulate the magnitude of the force applied during nebulization. Therefore, the same instrument can be used for very gentle opening of the cells as necessary in organelle isolation, or for thorough breakage of the cells when preparation of a cell extract is desired.

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